17.09.2026 20:15 • United States • NFL Regular Season 2026/2027

Buffalo Bills - Detroit Lions Predictions and Betting Tips

Buffalo Bills versus Detroit Lions takes place at 20:15 on 17.09.2026.

Buffalo Bills

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Detroit Lions

Choose your bet!

Check out the latest Buffalo Bills vs Detroit Lions betting picks and predictions chosen by the JohnnyBet Tipsters community. One of the most popular markets to bet on is "Home Away" and a predicted result of "Buffalo Bills" with odds of -217 from 1 out of 1 users.

The hottest bet types to choose from:

Home Away

Buffalo Bills

100%

1 out of 1 tipsters

JohnnyBet’s Betting Tips for Buffalo Bills - Detroit Lions by tipsters profit

Our most profitable tipster for this event, Expotips (ranking at 158 in overall Profit) is predicting 4.6 in profit by staking 10 on Buffalo Bills (-217) in Home Away bet.

Expotips

Rank: 158/1568

Profit: 44.76

10/10

JohnnyBet’s Betting Tips for Buffalo Bills - Detroit Lions by tipsters yield

If you trust yield more than profit, Expotips (with 3.21% overall yield) gives a prediction to get 4.6 profit by staking 10 on Buffalo Bills (-217) in Home Away market.

Expotips

Rank: 423/1568

Yield: 3.21%

10/10

JohnnyBet’s Betting Tips for Buffalo Bills - Detroit Lions by tipsters ODI

These tipsters know how to find best-value bets! Expotips, with an ODI parameter of -27.84 stakes 10 on odds of -217 for Buffalo Bills in Home Away market. It can bag a 4.6 profit.

Expotips

Rank: 1516/1568

ODI: -27.84

10/10

The best AI betting tips for Buffalo Bills vs Detroit Lions

What result for Buffalo Bills vs Detroit Lions does artificial intelligence predict? AI calculates that the most likely outcome is a bet on Buffalo Bills in the Home Away market, at odds of -217, with a stake of 10, from Expotips.

Expotips

10/10

See our tipsters predictions!

Discover the JohnnyBet community's betting tips for the next Buffalo Bills vs Detroit Lions game. The top prediction, with 100% of the votes, is a win for Buffalo Bills (odds of -217). While, a victory for Detroit Lions (+190) has collected 0% of the votes.

1 100%

2 0%

Buffalo Bills vs Detroit Lions Betting Tips

Tip 1:

Odds -217 for Buffalo Bills (Home Away)