22.05.2026 14:20 United States MLB 2026

Chicago Cubs - Houston Astros Predictions and Betting Tips

Chicago Cubs versus Houston Astros takes place at 14:20 on 22.05.2026.

Chicago Cubs
Chicago Cubs
Houston Astros
Houston Astros

Choose your bet!

Check out the latest Chicago Cubs vs Houston Astros betting picks and predictions chosen by the JohnnyBet Tipsters community. One of the most popular markets to bet on is "Home Away" and a predicted result of "Chicago Cubs" with odds of -145 from 2 out of 2 users.

The hottest bet types to choose from:

Home Away
Chicago Cubs
100%
2 out of 2 tipsters

JohnnyBet’s Betting Tips for Chicago Cubs - Houston Astros by tipsters profit

Our most profitable tipster for this event, Sport_Orakle (ranking at 4318 in overall Profit) is predicting 6.9 in profit by staking 10 on Chicago Cubs (-145) in Home Away bet. Jarecczak on the other hand (ranking at 4507), gives a tip on -139 for Chicago Cubs (Home Away) by staking 10 to get an estimated profit of 7.2.

Sport_Orakle
Sport_Orakle
Rank: 4318/4085
Profit: -1026.82
Home Away
-145 for Chicago Cubs
10/10
Estimated profit 6.90
Jarecczak
Jarecczak
Rank: 4507/4085
Profit: -6836.26
Home Away
-139 for Chicago Cubs
10/10
Estimated profit 7.20

JohnnyBet’s Betting Tips for Chicago Cubs - Houston Astros by tipsters yield

If you trust yield more than profit, Jarecczak (with -4.32% overall yield) gives a prediction to get 7.2 profit by staking 10 on Chicago Cubs (-139) in Home Away market. Then, there is Sport_Orakle with -7.18% yield. Giving a tip with 10 stake for Chicago Cubs (-145) in Home Away. The estimated profit is 6.9.

Jarecczak
Jarecczak
Rank: 1881/4085
Yield: -4.32%
Home Away
-139 for Chicago Cubs
10/10
Estimated profit 7.20
Sport_Orakle
Sport_Orakle
Rank: 2262/4085
Yield: -7.18%
Home Away
-145 for Chicago Cubs
10/10
Estimated profit 6.90

JohnnyBet’s Betting Tips for Chicago Cubs - Houston Astros by tipsters ODI

These tipsters know how to find best-value bets! Sport_Orakle, with an ODI parameter of -95.08 stakes 10 on odds of -145 for Chicago Cubs in Home Away market. It can bag a 6.9 profit. Jarecczak (ODI: -2350.5) placing betting tip to get 7.2 profit by putting 10 on Chicago Cubs (-139) in Home Away bet.

Sport_Orakle
Sport_Orakle
Rank: 4274/4085
ODI: -95.08
Home Away
-145 for Chicago Cubs
10/10
Estimated profit 6.90
Jarecczak
Jarecczak
Rank: 4486/4085
ODI: -2350.5
Home Away
-139 for Chicago Cubs
10/10
Estimated profit 7.20

The best AI betting tips for Chicago Cubs vs Houston Astros

What result for Chicago Cubs vs Houston Astros does artificial intelligence predict? AI calculates that the most likely outcome is a bet on Chicago Cubs in the Home Away market, at odds of -145, with a stake of 10, from Sport_Orakle. A bet on Chicago Cubs (-139) in the Home Away market with a stake of 10 from Jarecczak is another AI favourite.

Home Away
-145 for Chicago Cubs
10/10
Estimated profit 6.90
Home Away
-139 for Chicago Cubs
10/10
Estimated profit 7.20

See our tipsters predictions!

Discover the JohnnyBet community's betting tips for the next Chicago Cubs vs Houston Astros game. The top prediction, with 100% of the votes, is a win for Chicago Cubs (odds of -145). While, a victory for Houston Astros (+125) has collected 0% of the votes.

1 100%
2 0%

Chicago Cubs vs Houston Astros Betting Tips

Tip 1:
Odds -145 for Chicago Cubs (Home Away)
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