21.09.2025 14:10 United States MLB 2025

Chicago White Sox - San Diego Padres Predictions and Betting Tips

Chicago White Sox versus San Diego Padres takes place at 14:10 on 21.09.2025.

Chicago White Sox
Chicago White Sox
San Diego Padres
San Diego Padres

Choose your bet!

Check out the latest Chicago White Sox vs San Diego Padres betting picks and predictions chosen by the JohnnyBet Tipsters community. One of the most popular markets to bet on is "Home Away" and a predicted result of "Chicago White Sox" with odds of 2.46 from 1 out of 2 users. Another popular betting line is "Asian Handicap (1.5)" with a "San Diego Padres (-1.5), money back on draw" result (odds of 1.98) from 100%.

The hottest bet types to choose from:

Home Away
Chicago White Sox
50%
1 out of 2 tipsters
Over/Under 7.5
Under
100%
1 out of 1 tipsters
Over/Under 8.5
Over
100%
1 out of 1 tipsters

JohnnyBet’s Betting Tips for Chicago White Sox - San Diego Padres by tipsters profit

Our most profitable tipster for this event, Oleg Miami (ranking at 1089 in overall Profit) is predicting 13.14 in profit by staking 9 on Chicago White Sox (2.46) in Home Away bet. AMAYA on the other hand (ranking at 1518), gives a tip on 2.03 for Under (Over/Under 7.5) by staking 10 to get an estimated profit of 10.3. The third most profitable tipster (1526 this season), faro2013 estimates to get 9.8 in profit by staking 10 on 1.98 for San Diego Padres (-1.5), money back on draw in Asian Handicap (1.5) market.

Oleg Miami
Oleg Miami
Rank: 1089/1515
Profit: -74.47
Home Away
+146 for Chicago White Sox
9/10
Estimated profit 13.14
AMAYA
AMAYA
Rank: 1518/1515
Profit: -1338.0
Over/Under 7.5
+103 for Under
10/10
Estimated profit 10.30
faro2013
faro2013
Rank: 1526/1515
Profit: -1551.1
Asian Handicap (1.5)
-102 for San Diego Padres (-1.5), money back on draw
10/10
Estimated profit 9.80
faro2013
faro2013
Rank: 1526/1515
Profit: -1551.1
Over/Under 8.5
-109 for Over
10/10
Estimated profit 9.20
Antonhundballl
Antonhundballl
Rank: 1528/1515
Profit: -1593.56
Home Away
-169 for San Diego Padres
10/10
Estimated profit 5.90

JohnnyBet’s Betting Tips for Chicago White Sox - San Diego Padres by tipsters yield

If you trust yield more than profit, Oleg Miami (with -1.48% overall yield) gives a prediction to get 13.14 profit by staking 9 on Chicago White Sox (2.46) in Home Away market. Then, there is faro2013 with -4.52% yield. Giving a tip with 10 stake for San Diego Padres (-1.5), money back on draw (1.98) in Asian Handicap (1.5). The estimated profit is 9.8. Antonhundballl (-5.3% yield) picked 1.59 for San Diego Padres in Home Away market. Staking 10 will bring 5.9 profit if correct.

Oleg Miami
Oleg Miami
Rank: 554/1515
Yield: -1.48%
Home Away
+146 for Chicago White Sox
9/10
Estimated profit 13.14
faro2013
faro2013
Rank: 714/1515
Yield: -4.52%
Asian Handicap (1.5)
-102 for San Diego Padres (-1.5), money back on draw
10/10
Estimated profit 9.80
faro2013
faro2013
Rank: 714/1515
Yield: -4.52%
Over/Under 8.5
-109 for Over
10/10
Estimated profit 9.20
Antonhundballl
Antonhundballl
Rank: 755/1515
Yield: -5.3%
Home Away
-169 for San Diego Padres
10/10
Estimated profit 5.90
AMAYA
AMAYA
Rank: 1127/1515
Yield: -16.55%
Over/Under 7.5
+103 for Under
10/10
Estimated profit 10.30

JohnnyBet’s Betting Tips for Chicago White Sox - San Diego Padres by tipsters ODI

These tipsters know how to find best-value bets! Antonhundballl, with an ODI parameter of 3357.71 stakes 10 on odds of 1.59 for San Diego Padres in Home Away market. It can bag a 5.9 profit. AMAYA (ODI: 33.05) placing betting tip to get 10.3 profit by putting 10 on Under (2.03) in Over/Under 7.5 bet. Third in overall ranking (ODI: -8.36), Oleg Miami, chose Home Away market by going with an 9 stake on odds of 2.46 for Chicago White Sox, estimating profit of 13.14.

Antonhundballl
Antonhundballl
Rank: 1/1515
ODI: 3357.71
Home Away
-169 for San Diego Padres
10/10
Estimated profit 5.90
AMAYA
AMAYA
Rank: 86/1515
ODI: 33.05
Over/Under 7.5
+103 for Under
10/10
Estimated profit 10.30
Oleg Miami
Oleg Miami
Rank: 1289/1515
ODI: -8.36
Home Away
+146 for Chicago White Sox
9/10
Estimated profit 13.14
faro2013
faro2013
Rank: 1531/1515
ODI: -368.06
Asian Handicap (1.5)
-102 for San Diego Padres (-1.5), money back on draw
10/10
Estimated profit 9.80
faro2013
faro2013
Rank: 1531/1515
ODI: -368.06
Over/Under 8.5
-109 for Over
10/10
Estimated profit 9.20

The best AI betting tips for Chicago White Sox vs San Diego Padres

What result for Chicago White Sox vs San Diego Padres does artificial intelligence predict? AI calculates that the most likely outcome is a bet on San Diego Padres in the Home Away market, at odds of 1.59, with a stake of 10, from Antonhundballl. A bet on Chicago White Sox (2.46) in the Home Away market with a stake of 9 from Oleg Miami is another AI favourite. The third most likely winning bet according to the algorithm is Under in the Over/Under 7.5 market, on which AMAYA is placing 10 at odds of 2.03.

Antonhundballl
Antonhundballl
Home Away
-169 for San Diego Padres
10/10
Estimated profit 5.90
Oleg Miami
Oleg Miami
Home Away
+146 for Chicago White Sox
9/10
Estimated profit 13.14
AMAYA
AMAYA
Over/Under 7.5
+103 for Under
10/10
Estimated profit 10.30
faro2013
faro2013
Asian Handicap (1.5)
-102 for San Diego Padres (-1.5), money back on draw
10/10
Estimated profit 9.80
faro2013
faro2013
Over/Under 8.5
-109 for Over
10/10
Estimated profit 9.20

See our tipsters predictions!

Discover the JohnnyBet community's betting tips for the next Chicago White Sox vs San Diego Padres game. The top prediction, with 50% of the votes, is a win for Chicago White Sox (odds of 2.46). While, a victory for San Diego Padres (1.59) has collected 50% of the votes.

1 50%
2 50%

Chicago White Sox vs San Diego Padres Betting Tips

Tip 1:
Odds 2.46 for Chicago White Sox (Home Away)
Tip 2:
Odds 2.03 for Under (Over/Under 7.5)
Play responsibly 18+