11.01.2026 16:30 United States NFL 2025/2026

Philadelphia Eagles - San Francisco 49ers Predictions and Betting Tips

Philadelphia Eagles versus San Francisco 49ers takes place at 16:30 on 11.01.2026.

Philadelphia Eagles
Philadelphia Eagles
San Francisco 49ers
San Francisco 49ers

Choose your bet!

Check out the latest Philadelphia Eagles vs San Francisco 49ers betting picks and predictions chosen by the JohnnyBet Tipsters community. One of the most popular markets to bet on is "Home Away" and a predicted result of "San Francisco 49ers" with odds of 2.95 from 1 out of 2 users.

The hottest bet types to choose from:

Home Away
San Francisco 49ers
50%
1 out of 2 tipsters

JohnnyBet’s Betting Tips for Philadelphia Eagles - San Francisco 49ers by tipsters profit

Our most profitable tipster for this event, Juan heredia (ranking at 2393 in overall Profit) is predicting 4.8 in profit by staking 10 on Philadelphia Eagles (1.48) in Home Away bet. GamblingSport19 on the other hand (ranking at 2587), gives a tip on 2.95 for San Francisco 49ers (Home Away) by staking 10 to get an estimated profit of 19.5.

Juan heredia
Juan heredia
Rank: 2393/2684
Profit: -234.82
Home Away
-208 for Philadelphia Eagles
10/10
Estimated profit 4.80
GamblingSport19
GamblingSport19
Rank: 2587/2684
Profit: -534.23
Home Away
+195 for San Francisco 49ers
10/10
Estimated profit 19.50

JohnnyBet’s Betting Tips for Philadelphia Eagles - San Francisco 49ers by tipsters yield

If you trust yield more than profit, Juan heredia (with -1.39% overall yield) gives a prediction to get 4.8 profit by staking 10 on Philadelphia Eagles (1.48) in Home Away market. Then, there is GamblingSport19 with -4.37% yield. Giving a tip with 10 stake for San Francisco 49ers (2.95) in Home Away. The estimated profit is 19.5.

Juan heredia
Juan heredia
Rank: 932/2684
Yield: -1.39%
Home Away
-208 for Philadelphia Eagles
10/10
Estimated profit 4.80
GamblingSport19
GamblingSport19
Rank: 1209/2684
Yield: -4.37%
Home Away
+195 for San Francisco 49ers
10/10
Estimated profit 19.50

JohnnyBet’s Betting Tips for Philadelphia Eagles - San Francisco 49ers by tipsters ODI

These tipsters know how to find best-value bets! GamblingSport19, with an ODI parameter of 2.81 stakes 10 on odds of 2.95 for San Francisco 49ers in Home Away market. It can bag a 19.5 profit. Juan heredia (ODI: -78.21) placing betting tip to get 4.8 profit by putting 10 on Philadelphia Eagles (1.48) in Home Away bet.

GamblingSport19
GamblingSport19
Rank: 407/2684
ODI: 2.81
Home Away
+195 for San Francisco 49ers
10/10
Estimated profit 19.50
Juan heredia
Juan heredia
Rank: 2694/2684
ODI: -78.21
Home Away
-208 for Philadelphia Eagles
10/10
Estimated profit 4.80

The best AI betting tips for Philadelphia Eagles vs San Francisco 49ers

What result for Philadelphia Eagles vs San Francisco 49ers does artificial intelligence predict? AI calculates that the most likely outcome is a bet on Philadelphia Eagles in the Home Away market, at odds of 1.48, with a stake of 10, from Juan heredia. A bet on San Francisco 49ers (2.95) in the Home Away market with a stake of 10 from GamblingSport19 is another AI favourite.

Home Away
-208 for Philadelphia Eagles
10/10
Estimated profit 4.80
Home Away
+195 for San Francisco 49ers
10/10
Estimated profit 19.50

See our tipsters predictions!

Discover the JohnnyBet community's betting tips for the next Philadelphia Eagles vs San Francisco 49ers game. The top prediction, with 50% of the votes is a win for San Francisco 49ers (odds of 2.95). A victory for Philadelphia Eagles (1.48) has collected 50% of the votes.

1 50%
2 50%

Philadelphia Eagles vs San Francisco 49ers Betting Tips

Tip 1:
Odds 1.48 for Philadelphia Eagles (Home Away)
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