21.05.2026 13:15 United States MLB 2026

St. Louis Cardinals - Pittsburgh Pirates Predictions and Betting Tips

St. Louis Cardinals versus Pittsburgh Pirates takes place at 13:15 on 21.05.2026.

St. Louis Cardinals
Pittsburgh Pirates
Pittsburgh Pirates

Choose your bet!

Check out the latest St. Louis Cardinals vs Pittsburgh Pirates betting picks and predictions chosen by the JohnnyBet Tipsters community. One of the most popular markets to bet on is "Home Away" and a predicted result of "Pittsburgh Pirates" with odds of -122 from 3 out of 4 users.

The hottest bet types to choose from:

Home Away
Pittsburgh Pirates
75%
3 out of 4 tipsters

JohnnyBet’s Betting Tips for St. Louis Cardinals - Pittsburgh Pirates by tipsters profit

Our most profitable tipster for this event, Sylwester Zalewski (ranking at 24 in overall Profit) is predicting 8.2 in profit by staking 10 on Pittsburgh Pirates (-122) in Home Away bet. soap_mactavish on the other hand (ranking at 4237), gives a tip on -125 for Pittsburgh Pirates (Home Away) by staking 10 to get an estimated profit of 8.0. The third most profitable tipster (4348 this season), viveiron estimates to get 8.2 in profit by staking 10 on -122 for Pittsburgh Pirates in Home Away market.

Sylwester Zalewski
Rank: 24/4079
Profit: 273.74
Home Away
-122 for Pittsburgh Pirates
10/10
Estimated profit 8.20
soap_mactavish
soap_mactavish
Rank: 4237/4079
Profit: -788.7
Home Away
-125 for Pittsburgh Pirates
10/10
Estimated profit 8.00
viveiron
viveiron
Rank: 4348/4079
Profit: -1496.95
Home Away
-122 for Pittsburgh Pirates
10/10
Estimated profit 8.20
Al7777777
Al7777777
Rank: 4462/4079
Profit: -4289.69
Home Away
+113 for St. Louis Cardinals
10/10
Estimated profit 11.30

JohnnyBet’s Betting Tips for St. Louis Cardinals - Pittsburgh Pirates by tipsters yield

If you trust yield more than profit, Sylwester Zalewski (with 15.92% overall yield) gives a prediction to get 8.2 profit by staking 10 on Pittsburgh Pirates (-122) in Home Away market. Then, there is soap_mactavish with -2.11% yield. Giving a tip with 10 stake for Pittsburgh Pirates (-125) in Home Away. The estimated profit is 8.0. viveiron (-3.1% yield) picked -122 for Pittsburgh Pirates in Home Away market. Staking 10 will bring 8.2 profit if correct.

Sylwester Zalewski
Rank: 774/4079
Yield: 15.92%
Home Away
-122 for Pittsburgh Pirates
10/10
Estimated profit 8.20
soap_mactavish
soap_mactavish
Rank: 1533/4079
Yield: -2.11%
Home Away
-125 for Pittsburgh Pirates
10/10
Estimated profit 8.00
viveiron
viveiron
Rank: 1678/4079
Yield: -3.1%
Home Away
-122 for Pittsburgh Pirates
10/10
Estimated profit 8.20
Al7777777
Al7777777
Rank: 2255/4079
Yield: -7.24%
Home Away
+113 for St. Louis Cardinals
10/10
Estimated profit 11.30

JohnnyBet’s Betting Tips for St. Louis Cardinals - Pittsburgh Pirates by tipsters ODI

These tipsters know how to find best-value bets! Sylwester Zalewski, with an ODI parameter of 5.26 stakes 10 on odds of -122 for Pittsburgh Pirates in Home Away market. It can bag a 8.2 profit. soap_mactavish (ODI: -277.54) placing betting tip to get 8.0 profit by putting 10 on Pittsburgh Pirates (-125) in Home Away bet. Third in overall ranking (ODI: -1223.35), viveiron, chose Home Away market by going with an 10 stake on odds of -122 for Pittsburgh Pirates, estimating profit of 8.2.

Sylwester Zalewski
Rank: 508/4079
ODI: 5.26
Home Away
-122 for Pittsburgh Pirates
10/10
Estimated profit 8.20
soap_mactavish
soap_mactavish
Rank: 4360/4079
ODI: -277.54
Home Away
-125 for Pittsburgh Pirates
10/10
Estimated profit 8.00
viveiron
viveiron
Rank: 4441/4079
ODI: -1223.35
Home Away
-122 for Pittsburgh Pirates
10/10
Estimated profit 8.20
Al7777777
Al7777777
Rank: 4476/4079
ODI: -4860.34
Home Away
+113 for St. Louis Cardinals
10/10
Estimated profit 11.30

The best AI betting tips for St. Louis Cardinals vs Pittsburgh Pirates

What result for St. Louis Cardinals vs Pittsburgh Pirates does artificial intelligence predict? AI calculates that the most likely outcome is a bet on Pittsburgh Pirates in the Home Away market, at odds of -122, with a stake of 10, from Sylwester Zalewski. A bet on Pittsburgh Pirates (-125) in the Home Away market with a stake of 10 from soap_mactavish is another AI favourite. The third most likely winning bet according to the algorithm is Pittsburgh Pirates in the Home Away market, on which viveiron is placing 10 at odds of -122.

Home Away
-122 for Pittsburgh Pirates
10/10
Estimated profit 8.20
Home Away
-125 for Pittsburgh Pirates
10/10
Estimated profit 8.00
Home Away
-122 for Pittsburgh Pirates
10/10
Estimated profit 8.20
Home Away
+113 for St. Louis Cardinals
10/10
Estimated profit 11.30

See our tipsters predictions!

Discover the JohnnyBet community's betting tips for the next St. Louis Cardinals vs Pittsburgh Pirates game. The top prediction, with 75% of the votes is a win for Pittsburgh Pirates (odds of -122). A victory for St. Louis Cardinals (+113) has collected 25% of the votes.

1 25%
2 75%

St. Louis Cardinals vs Pittsburgh Pirates Betting Tips

Tip 1:
Odds -122 for Pittsburgh Pirates (Home Away)
Play responsibly 21+