12.10.2025 16:25 • United States • NFL 2025/2026

Tampa Bay Buccaneers - San Francisco 49ers Predictions and Betting Tips

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Tampa Bay Buccaneers versus San Francisco 49ers takes place at 16:25 on 12.10.2025.

Tampa Bay Buccaneers

—

San Francisco 49ers

Choose your bet!

Check out the latest Tampa Bay Buccaneers vs San Francisco 49ers betting picks and predictions chosen by the JohnnyBet Tipsters community. One of the most popular markets to bet on is "Home Away" and a predicted result of "San Francisco 49ers" with odds of 2.37 from 1 out of 2 users.

The hottest bet types to choose from:

Home Away

San Francisco 49ers

50%

1 out of 2 tipsters

Over/Under 52.5

Under

100%

1 out of 1 tipsters

JohnnyBet’s Betting Tips for Tampa Bay Buccaneers - San Francisco 49ers by tipsters profit

Our most profitable tipster for this event, Juri777 (ranking at 1736 in overall Profit) is predicting 13.7 in profit by staking 10 on San Francisco 49ers (2.37) in Home Away bet. markus25 on the other hand (ranking at 1765), gives a tip on 1.65 for Tampa Bay Buccaneers (Home Away) by staking 10 to get an estimated profit of 6.5.

Juri777

Rank: 1736/1747

Profit: -1019.48

10/10

Estimated profit 13.70

Juri777

Rank: 1736/1747

Profit: -1019.48

10/10

Estimated profit 4.60

markus25

Rank: 1765/1747

Profit: -1596.37

10/10

Estimated profit 6.50

JohnnyBet’s Betting Tips for Tampa Bay Buccaneers - San Francisco 49ers by tipsters yield

If you trust yield more than profit, markus25 (with -3.93% overall yield) gives a prediction to get 6.5 profit by staking 10 on Tampa Bay Buccaneers (1.65) in Home Away market. Then, there is Juri777 with -5.99% yield. Giving a tip with 10 stake for San Francisco 49ers (2.37) in Home Away. The estimated profit is 13.7.

markus25

Rank: 764/1747

Yield: -3.93%

10/10

Estimated profit 6.50

Juri777

Rank: 915/1747

Yield: -5.99%

10/10

Estimated profit 13.70

Juri777

Rank: 915/1747

Yield: -5.99%

10/10

Estimated profit 4.60

JohnnyBet’s Betting Tips for Tampa Bay Buccaneers - San Francisco 49ers by tipsters ODI

These tipsters know how to find best-value bets! Juri777, with an ODI parameter of -110.7 stakes 10 on odds of 2.37 for San Francisco 49ers in Home Away market. It can bag a 13.7 profit. markus25 (ODI: -498.46) placing betting tip to get 6.5 profit by putting 10 on Tampa Bay Buccaneers (1.65) in Home Away bet.

Juri777

Rank: 1746/1747

ODI: -110.7

10/10

Estimated profit 13.70

Juri777

Rank: 1746/1747

ODI: -110.7

10/10

Estimated profit 4.60

markus25

Rank: 1784/1747

ODI: -498.46

10/10

Estimated profit 6.50

The best AI betting tips for Tampa Bay Buccaneers vs San Francisco 49ers

What result for Tampa Bay Buccaneers vs San Francisco 49ers does artificial intelligence predict? AI calculates that the most likely outcome is a bet on Under in the Over/Under 52.5 market, at odds of 1.46, with a stake of 10, from Juri777. A bet on Tampa Bay Buccaneers (1.65) in the Home Away market with a stake of 10 from markus25 is another AI favourite.

Juri777

10/10

Estimated profit 4.60

Juri777

10/10

Estimated profit 13.70

markus25

10/10

Estimated profit 6.50

See our tipsters predictions!

Discover the JohnnyBet community's betting tips for the next Tampa Bay Buccaneers vs San Francisco 49ers game. The top prediction, with 50% of the votes is a win for San Francisco 49ers (odds of 2.37). A victory for Tampa Bay Buccaneers (1.65) has collected 50% of the votes.

1 50%

2 50%

How to watch Tampa Bay Buccaneers vs San Francisco 49ers Live Stream

You can watch Tampa Bay Buccaneers vs San Francisco 49ers live at 16:25 on 2025-10-12 thanks to bet365 live streaming services. Check the available options on the global listing below.

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Tampa Bay Buccaneers vs San Francisco 49ers Betting Tips

Tip 1:

Odds 2.37 for San Francisco 49ers (Home Away)

Tip 2:

Odds 1.46 for Under (Over/Under 52.5)