28.09.2025 15:20 • United States • MLB 2025

Chicago Cubs - St. Louis Cardinals Predictions and Betting Tips

Chicago Cubs versus St. Louis Cardinals takes place at 15:20 on 28.09.2025.

Chicago Cubs

—

St. Louis Cardinals

Choose your bet!

Check out the latest Chicago Cubs vs St. Louis Cardinals betting picks and predictions chosen by the JohnnyBet Tipsters community. One of the most popular markets to bet on is "Home Away" and a predicted result of "Chicago Cubs" with odds of 1.62 from 2 out of 3 users.

The hottest bet types to choose from:

Home Away

Chicago Cubs

67%

2 out of 3 tipsters

Over/Under 7.5

Under

100%

1 out of 1 tipsters

JohnnyBet’s Betting Tips for Chicago Cubs - St. Louis Cardinals by tipsters profit

Our most profitable tipster for this event, Oleg Miami (ranking at 1418 in overall Profit) is predicting 6.2 in profit by staking 10 on Chicago Cubs (1.62) in Home Away bet. KAKTUSZ29 on the other hand (ranking at 1589), gives a tip on 2.4 for St. Louis Cardinals (Home Away) by staking 10 to get an estimated profit of 14.0. The third most profitable tipster (1613 this season), AMAYA estimates to get 10.7 in profit by staking 10 on 2.07 for Under in Over/Under 7.5 market.

Oleg Miami

Rank: 1418/1611

Profit: -251.89

10/10

Estimated profit 6.20

KAKTUSZ29

Rank: 1589/1611

Profit: -917.21

10/10

Estimated profit 14.00

AMAYA

Rank: 1613/1611

Profit: -1144.38

10/10

Estimated profit 10.70

Mig834

Rank: 1622/1611

Profit: -1295.47

10/10

Estimated profit 6.10

JohnnyBet’s Betting Tips for Chicago Cubs - St. Louis Cardinals by tipsters yield

If you trust yield more than profit, Oleg Miami (with -3.65% overall yield) gives a prediction to get 6.2 profit by staking 10 on Chicago Cubs (1.62) in Home Away market. Then, there is Mig834 with -4.05% yield. Giving a tip with 10 stake for Chicago Cubs (1.61) in Home Away. The estimated profit is 6.1. KAKTUSZ29 (-4.34% yield) picked 2.4 for St. Louis Cardinals in Home Away market. Staking 10 will bring 14.0 profit if correct.

Oleg Miami

Rank: 670/1611

Yield: -3.65%

10/10

Estimated profit 6.20

Mig834

Rank: 695/1611

Yield: -4.05%

10/10

Estimated profit 6.10

KAKTUSZ29

Rank: 713/1611

Yield: -4.34%

10/10

Estimated profit 14.00

AMAYA

Rank: 1071/1611

Yield: -11.65%

10/10

Estimated profit 10.70

JohnnyBet’s Betting Tips for Chicago Cubs - St. Louis Cardinals by tipsters ODI

These tipsters know how to find best-value bets! AMAYA, with an ODI parameter of 27.33 stakes 10 on odds of 2.07 for Under in Over/Under 7.5 market. It can bag a 10.7 profit. Oleg Miami (ODI: -9.26) placing betting tip to get 6.2 profit by putting 10 on Chicago Cubs (1.62) in Home Away bet. Third in overall ranking (ODI: -25.98), Mig834, chose Home Away market by going with an 10 stake on odds of 1.61 for Chicago Cubs, estimating profit of 6.1.

AMAYA

Rank: 100/1611

ODI: 27.33

10/10

Estimated profit 10.70

Oleg Miami

Rank: 1402/1611

ODI: -9.26

10/10

Estimated profit 6.20

Mig834

Rank: 1516/1611

ODI: -25.98

10/10

Estimated profit 6.10

KAKTUSZ29

Rank: 1528/1611

ODI: -28.79

10/10

Estimated profit 14.00

The best AI betting tips for Chicago Cubs vs St. Louis Cardinals

What result for Chicago Cubs vs St. Louis Cardinals does artificial intelligence predict? AI calculates that the most likely outcome is a bet on Chicago Cubs in the Home Away market, at odds of 1.62, with a stake of 10, from Oleg Miami. A bet on St. Louis Cardinals (2.4) in the Home Away market with a stake of 10 from KAKTUSZ29 is another AI favourite. The third most likely winning bet according to the algorithm is Under in the Over/Under 7.5 market, on which AMAYA is placing 10 at odds of 2.07.

Oleg Miami

10/10

Estimated profit 6.20

KAKTUSZ29

10/10

Estimated profit 14.00

AMAYA

10/10

Estimated profit 10.70

Mig834

10/10

Estimated profit 6.10

See our tipsters predictions!

Discover the JohnnyBet community's betting tips for the next Chicago Cubs vs St. Louis Cardinals game. The top prediction, with 67% of the votes, is a win for Chicago Cubs (odds of 1.62). While, a victory for St. Louis Cardinals (2.4) has collected 33% of the votes.

1 67%

2 33%

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How to watch Chicago Cubs vs St. Louis Cardinals Live Stream

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Chicago Cubs vs St. Louis Cardinals Betting Tips

Tip 1:

Odds 1.62 for Chicago Cubs (Home Away)

Tip 2:

Odds 2.07 for Under (Over/Under 7.5)