22.12.2025 20:15 United States NFL 2025/2026

Indianapolis Colts - San Francisco 49ers Predictions and Betting Tips

Indianapolis Colts versus San Francisco 49ers takes place at 20:15 on 22.12.2025.

Indianapolis Colts
Indianapolis Colts
San Francisco 49ers
San Francisco 49ers

Choose your bet!

Check out the latest Indianapolis Colts vs San Francisco 49ers betting picks and predictions chosen by the JohnnyBet Tipsters community. One of the most popular markets to bet on is "Home Away" and a predicted result of "San Francisco 49ers" with odds of 1.41 from 1 out of 1 users. Another popular betting line is "Asian Handicap (7.5)" with a "Indianapolis Colts (+7.5), money back on draw" result (odds of 1.62) from 100%.

The hottest bet types to choose from:

Home Away
San Francisco 49ers
100%
1 out of 1 tipsters
Asian Handicap (7.5)
Indianapolis Colts (+7.5), money back on draw
100%
1 out of 1 tipsters

JohnnyBet’s Betting Tips for Indianapolis Colts - San Francisco 49ers by tipsters profit

Our most profitable tipster for this event, yeli03 (ranking at 102 in overall Profit) is predicting 6.2 in profit by staking 10 on Indianapolis Colts (+7.5), money back on draw (1.62) in Asian Handicap (7.5) bet. The Engineer on the other hand (ranking at 2470), gives a tip on 1.41 for San Francisco 49ers (Home Away) by staking 10 to get an estimated profit of 4.1.

yeli03
yeli03
Rank: 102/2551
Profit: 51.1
Asian Handicap (7.5)
-161 for Indianapolis Colts (+7.5), money back on draw
10/10
Estimated profit 6.20
The Engineer
The Engineer
Rank: 2470/2551
Profit: -508.75
Home Away
-244 for San Francisco 49ers
10/10
Estimated profit 4.10

JohnnyBet’s Betting Tips for Indianapolis Colts - San Francisco 49ers by tipsters yield

If you trust yield more than profit, yeli03 (with 2.84% overall yield) gives a prediction to get 6.2 profit by staking 10 on Indianapolis Colts (+7.5), money back on draw (1.62) in Asian Handicap (7.5) market. Then, there is The Engineer with -2.53% yield. Giving a tip with 10 stake for San Francisco 49ers (1.41) in Home Away. The estimated profit is 4.1.

yeli03
yeli03
Rank: 667/2551
Yield: 2.84%
Asian Handicap (7.5)
-161 for Indianapolis Colts (+7.5), money back on draw
10/10
Estimated profit 6.20
The Engineer
The Engineer
Rank: 971/2551
Yield: -2.53%
Home Away
-244 for San Francisco 49ers
10/10
Estimated profit 4.10

JohnnyBet’s Betting Tips for Indianapolis Colts - San Francisco 49ers by tipsters ODI

These tipsters know how to find best-value bets! The Engineer, with an ODI parameter of -11.87 stakes 10 on odds of 1.41 for San Francisco 49ers in Home Away market. It can bag a 4.1 profit. yeli03 (ODI: -24.11) placing betting tip to get 6.2 profit by putting 10 on Indianapolis Colts (+7.5), money back on draw (1.62) in Asian Handicap (7.5) bet.

The Engineer
The Engineer
Rank: 2331/2551
ODI: -11.87
Home Away
-244 for San Francisco 49ers
10/10
Estimated profit 4.10
yeli03
yeli03
Rank: 2446/2551
ODI: -24.11
Asian Handicap (7.5)
-161 for Indianapolis Colts (+7.5), money back on draw
10/10
Estimated profit 6.20

The best AI betting tips for Indianapolis Colts vs San Francisco 49ers

What result for Indianapolis Colts vs San Francisco 49ers does artificial intelligence predict? AI calculates that the most likely outcome is a bet on Indianapolis Colts (+7.5), money back on draw in the Asian Handicap (7.5) market, at odds of 1.62, with a stake of 10, from yeli03. A bet on San Francisco 49ers (1.41) in the Home Away market with a stake of 10 from The Engineer is another AI favourite.

Asian Handicap (7.5)
-161 for Indianapolis Colts (+7.5), money back on draw
10/10
Estimated profit 6.20
Home Away
-244 for San Francisco 49ers
10/10
Estimated profit 4.10

See our tipsters predictions!

Discover the JohnnyBet community's betting tips for the next Indianapolis Colts vs San Francisco 49ers game. The top prediction, with 100% of the votes is a win for San Francisco 49ers (odds of 1.41). A victory for Indianapolis Colts (3.24) has collected 0% of the votes.

1 0%
2 100%

Indianapolis Colts vs San Francisco 49ers Betting Tips

Tip 1:
Odds 1.62 for Indianapolis Colts (+7.5), money back on draw (Asian Handicap (7.5))
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