28.09.2025 16:05 • United States • NFL 2025/2026

San Francisco 49ers - Jacksonville Jaguars Predictions and Betting Tips

San Francisco 49ers versus Jacksonville Jaguars takes place at 16:05 on 28.09.2025.

San Francisco 49ers

—

Jacksonville Jaguars

Choose your bet!

Check out the latest San Francisco 49ers vs Jacksonville Jaguars betting picks and predictions chosen by the JohnnyBet Tipsters community. One of the most popular markets to bet on is "Home Away" and a predicted result of "Jacksonville Jaguars" with odds of 2.4 from 1 out of 1 users.

The hottest bet types to choose from:

Over/Under 48.5

Over

100%

1 out of 1 tipsters

Home Away

Jacksonville Jaguars

100%

1 out of 1 tipsters

JohnnyBet’s Betting Tips for San Francisco 49ers - Jacksonville Jaguars by tipsters profit

Our most profitable tipster for this event, faro2013 (ranking at 1588 in overall Profit) is predicting 14.0 in profit by staking 10 on Jacksonville Jaguars (2.4) in Home Away bet.

faro2013

Rank: 1588/1582

Profit: -1881.92

10/10

Estimated profit 14.00

faro2013

Rank: 1588/1582

Profit: -1881.92

10/10

Estimated profit 9.00

JohnnyBet’s Betting Tips for San Francisco 49ers - Jacksonville Jaguars by tipsters yield

If you trust yield more than profit, faro2013 (with -5.09% overall yield) gives a prediction to get 14.0 profit by staking 10 on Jacksonville Jaguars (2.4) in Home Away market.

faro2013

Rank: 752/1582

Yield: -5.09%

10/10

Estimated profit 14.00

faro2013

Rank: 752/1582

Yield: -5.09%

10/10

Estimated profit 9.00

JohnnyBet’s Betting Tips for San Francisco 49ers - Jacksonville Jaguars by tipsters ODI

These tipsters know how to find best-value bets! faro2013, with an ODI parameter of -378.67 stakes 10 on odds of 2.4 for Jacksonville Jaguars in Home Away market. It can bag a 14.0 profit.

faro2013

Rank: 1593/1582

ODI: -378.67

10/10

Estimated profit 14.00

faro2013

Rank: 1593/1582

ODI: -378.67

10/10

Estimated profit 9.00

The best AI betting tips for San Francisco 49ers vs Jacksonville Jaguars

What result for San Francisco 49ers vs Jacksonville Jaguars does artificial intelligence predict? AI calculates that the most likely outcome is a bet on Jacksonville Jaguars in the Home Away market, at odds of 2.4, with a stake of 10, from faro2013.

faro2013

10/10

Estimated profit 14.00

faro2013

10/10

Estimated profit 9.00

See our tipsters predictions!

Discover the JohnnyBet community's betting tips for the next San Francisco 49ers vs Jacksonville Jaguars game. The top prediction, with 100% of the votes is a win for Jacksonville Jaguars (odds of 2.4). A victory for San Francisco 49ers (1.59) has collected 0% of the votes.

1 0%

2 100%

bet365

How to watch San Francisco 49ers vs Jacksonville Jaguars Live Stream

You can watch San Francisco 49ers vs Jacksonville Jaguars live at 16:05 on 2025-09-28 thanks to bet365 live streaming services. Check the available options on the global listing below.

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San Francisco 49ers vs Jacksonville Jaguars Betting Tips

Tip 1:

Odds 2.4 for Jacksonville Jaguars (Home Away)

Tip 2:

Odds 1.9 for Over (Over/Under 48.5)