23.08.2025 20:30 United States NFL Preseason 2025

San Francisco 49ers - Los Angeles Chargers Predictions and Betting Tips

San Francisco 49ers versus Los Angeles Chargers takes place at 20:30 on 23.08.2025.

San Francisco 49ers
San Francisco 49ers
Los Angeles Chargers

Choose your bet!

Check out the latest San Francisco 49ers vs Los Angeles Chargers betting picks and predictions chosen by the JohnnyBet Tipsters community. One of the most popular markets to bet on is "Asian Handicap (-4.5)" and a predicted result of "San Francisco 49ers (-4.5), money back on draw" with odds of 1.77 from 1 out of 1 users.

The hottest bet types to choose from:

Asian Handicap (-4.5)
San Francisco 49ers (-4.5), money back on draw
100%
1 out of 1 tipsters

JohnnyBet’s Betting Tips for San Francisco 49ers - Los Angeles Chargers by tipsters profit

Our most profitable tipster for this event, killoso (ranking at 1005 in overall Profit) is predicting 7.7 in profit by staking 10 on San Francisco 49ers (-4.5), money back on draw (1.77) in Asian Handicap (-4.5) bet.

killoso
killoso
Rank: 1005/1055
Profit: -117.04
Asian Handicap (-4.5)
-130 for San Francisco 49ers (-4.5), money back on draw
10/10
Estimated profit 7.70

JohnnyBet’s Betting Tips for San Francisco 49ers - Los Angeles Chargers by tipsters yield

If you trust yield more than profit, killoso (with -4.58% overall yield) gives a prediction to get 7.7 profit by staking 10 on San Francisco 49ers (-4.5), money back on draw (1.77) in Asian Handicap (-4.5) market.

killoso
killoso
Rank: 544/1055
Yield: -4.58%
Asian Handicap (-4.5)
-130 for San Francisco 49ers (-4.5), money back on draw
10/10
Estimated profit 7.70

JohnnyBet’s Betting Tips for San Francisco 49ers - Los Angeles Chargers by tipsters ODI

These tipsters know how to find best-value bets! killoso, with an ODI parameter of -8.07 stakes 10 on odds of 1.77 for San Francisco 49ers (-4.5), money back on draw in Asian Handicap (-4.5) market. It can bag a 7.7 profit.

killoso
killoso
Rank: 1075/1055
ODI: -8.07
Asian Handicap (-4.5)
-130 for San Francisco 49ers (-4.5), money back on draw
10/10
Estimated profit 7.70

The best AI betting tips for San Francisco 49ers vs Los Angeles Chargers

What result for San Francisco 49ers vs Los Angeles Chargers does artificial intelligence predict? AI calculates that the most likely outcome is a bet on San Francisco 49ers (-4.5), money back on draw in the Asian Handicap (-4.5) market, at odds of 1.77, with a stake of 10, from killoso.

killoso
killoso
Asian Handicap (-4.5)
-130 for San Francisco 49ers (-4.5), money back on draw
10/10
Estimated profit 7.70

San Francisco 49ers vs Los Angeles Chargers Betting Tips

Tip 1:
Odds 1.77 for San Francisco 49ers (-4.5), money back on draw (Asian Handicap (-4.5))
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